Guanine nucleotides and pertussis toxin alter agonist binding to rat septal V(1)-vasopressin receptors.

Abstract

To investigate whether the rat brain vasopressin receptor is coupled to phospholipase C by a GTP-binding protein, the effects of guanine nucleotides and pertussis toxin on agonist binding to septal membranes were examined. Synaptic plasma membranes were prepared from rat septal tissue and binding of [(3)H]AVP was examined in the presence of guanine… (More)

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