Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.

@article{Milligan1987GuanineNR,
  title={Guanine nucleotide regulation of the pertussis and cholera toxin substrates of rat glioma C6 BU1 cells.},
  author={Graeme Milligan},
  journal={Biochimica et biophysica acta},
  year={1987},
  volume={929 2},
  pages={197-202}
}
Rat glioma C6 BU1 cells contain a pertussis toxin substrate of 40 kDa which does not appear to be identical with Gi,Go or transducin. The GTP analogue, GTP[gamma S], inhibited the rate of pertussis toxin-catalysed ADPribosylation of this protein, while the GDP analogue GDP[beta S] stimulated this reaction. A protein of the same kDa value was ADPribosylated by cholera toxin in the absence of added guanine nucleotides. It is suggested that this 40 kDa protein can be a substrate for both cholera… CONTINUE READING

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