Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.

@article{Herroeder2009GuanineNP,
  title={Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.},
  author={Susanne Herroeder and Peter Reichardt and Antonia Sassmann and Barbara Zimmermann and Dagmar Jaeneke and Jana Hoeckner and Markus W Hollmann and K Fischer and Stephan Vogt and Robert Grosse and Nancy Hogg and Matthias Gunzer and Stefan Offermanns and Nina Wettschureck},
  journal={Immunity},
  year={2009},
  volume={30 5},
  pages={708-20}
}
Integrin-mediated adhesion plays a central role in T cell trafficking and activation. Genetic inactivation of the guanine nucleotide-binding (G) protein alpha-subunits Galpha(12) and Galpha(13) resulted in an increased activity of integrin leukocyte-function-antigen-1 in murine CD4(+) T cells. The interaction with allogeneic dendritic cells was enhanced, leading to an abnormal proliferative response in vitro. In vivo, T cell-specific inactivation of Galpha(12) and Galpha(13) caused… CONTINUE READING

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