Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.

@article{Richardson1992GuanineNP,
  title={Guanine nucleotide-binding protein-coupled and -uncoupled states of opioid receptors and their relevance to the determination of subtypes.},
  author={A Richardson and Catherine D Demoliou-Mason and E. A. B. Barnard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 21},
  pages={
          10198-202
        }
}
Opioid receptors are currently classified as mu, delta, and kappa types, but various subtypes have also been proposed. We have investigated whether subtypes exist by using [3H]bremazocine. [3H]Bremazocine binds to twice as many naloxone-sensitive sites as other nonselective opioid agonists, as shown in four membrane types that have very different ratios of mu, delta, and kappa receptor types. [3H]Bremazocine binding is completely inhibited by an excess (in unlabeled form) of other opioid… CONTINUE READING

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References

Publications referenced by this paper.

Outlines of Receptor Theory (Elsevier, Amsterdam)

L. E. Robson, M.G.C. Gillan, H. W. Kosterlitz
  • Biochem. Biophys. Res
  • 1985

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