Guanidinoacetate methyltransferase in the mouse: extensive expression in Sertoli cells of testis and in microvilli of caput epididymis.

@article{Lee1994GuanidinoacetateMI,
  title={Guanidinoacetate methyltransferase in the mouse: extensive expression in Sertoli cells of testis and in microvilli of caput epididymis.},
  author={Hubert W. Lee and Hirofumi Ogawa and Makio Fujioka and George L. Gerton},
  journal={Biology of reproduction},
  year={1994},
  volume={50 1},
  pages={152-62}
}
Guanidinoacetate methyltransferase (GAMT) catalyzes the last step of the biosynthetic pathway to creatine (Cr), the transfer of a methyl group from S-adenosylmethionine to guanidinoactate. Despite the importance of this methylation reaction in cellular energy metabolism and in methyl group metabolism, a systematic study of the expression and cellular localization of this enzyme is lacking. As a means for determining why the testis and seminal vesicles contain high levels of Cr, we analyzed GAMT… CONTINUE READING

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These results indicate that Cr is synthesized extensively in the epithelia of seminiferous tubules and caput epididymis , suggesting that GAMT or metabolic pathways related to Cr biosynthesis may be important for germ cell development or function .
These results indicate that Cr is synthesized extensively in the epithelia of seminiferous tubules and caput epididymis , suggesting that GAMT or metabolic pathways related to Cr biosynthesis may be important for germ cell development or function .
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