Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).

  title={Guanidine alkaloids and Pictet-Spengler adducts from black cohosh (Cimicifuga racemosa).},
  author={T. G{\"o}decke and D. Lankin and D. Nikolic and S. Chen and R. V. van Breemen and N. Farnsworth and G. Pauli},
  journal={Journal of natural products},
  volume={72 3},
  • T. Gödecke, D. Lankin, +4 authors G. Pauli
  • Published 2009
  • Chemistry, Medicine
  • Journal of natural products
  • As an extension of work on the recently discovered nitrogenous metabolites from Cimicifuga/Actaea species, three new guanidine alkaloids have been isolated and characterized from C. racemosa (syn. A. racemosa) roots. Of these, cyclo-cimipronidine (1) and cimipronidine methyl ester (2) are congeners of cimipronidine (3), whereas dopargine (5) is a derivative of dopamine. By employing NMR- and MS-guided chemodiversity profiling of a polar serotonergic (5-HT(7)) fraction, the guanidine alkaloids… CONTINUE READING
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