Guanfacine, But Not Clonidine, Improves Planning and Working Memory Performance in Humans

@article{Jkl1999GuanfacineBN,
  title={Guanfacine, But Not Clonidine, Improves Planning and Working Memory Performance in Humans},
  author={Pekka J{\"a}k{\"a}l{\"a} and Minna Riekkinen and Jouni Sirvi{\"o} and Esa H Koivisto and Kosti Kejonen and Vanhanen and Paavo Riekkinen},
  journal={Neuropsychopharmacology},
  year={1999},
  volume={20},
  pages={460-470}
}
The present study compares, using a double-blind, placebo controlled design the effects of two α2-agonists, clonidine (0.5, 2, and 5 μg/kg) and guanfacine (7 and 29 μg/kg) on spatial working memory, planning and attentional set-shifting, functions thought to be dependent on the “central executive” of the prefrontal cortex. Blood pressure and the subjective feeling of sedation were affected equally by clonidine and guanfacine. The 0.5 μg/kg and 5 μg/kg doses of clonidine disrupted spatial… CONTINUE READING
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Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: A positron emission tomography study

  • AM Owen, AC Evans, M Patrides
  • Cereb Cortex
  • 1996
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