GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle.

@article{Jewett2009GuaAAG,
  title={GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle.},
  author={Mollie W Jewett and Kevin A. Lawrence and Aaron C Bestor and Rebecca Byram and Frank C Gherardini and Patricia A Rosa},
  journal={Journal of bacteriology},
  year={2009},
  volume={191 20},
  pages={6231-41}
}
Pathogens lacking the enzymatic pathways for de novo purine biosynthesis are required to salvage purines and pyrimidines from the host environment for synthesis of DNA and RNA. Two key enzymes in purine salvage pathways are IMP dehydrogenase (GuaB) and GMP synthase (GuaA), encoded by the guaB and guaA genes, respectively. While these genes are typically found on the chromosome in most bacterial pathogens, the guaAB operon of Borrelia burgdorferi is present on plasmid cp26, which also harbors a… CONTINUE READING

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Biosynthesis of purine nucleotides, p. 561–579

  • H. Zalkin, P. Nygaard
  • Escherichia coli and Salmonella: cellular and…
  • 1996
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