Gsk3β is required in the epithelium for palatal elevation in mice.

  title={Gsk3β is required in the epithelium for palatal elevation in mice.},
  author={Fenglei He and Anthony P. Popkie and Wei Xiong and Lu Li and Ying Wang and Christopher J Phiel and Yiping Chen},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={239 12},
In Wnt/β-catenin signaling pathway, Gsk3β functions to facilitate β-catenin degradation. Inactivation of Gsk3β in mice causes a cleft palate formation, suggesting an involvement of Wnt/β-catenin signaling during palatogenesis. In this study, we have investigated the expression pattern, tissue-specific requirement and function of Gsk3β during mouse palatogenesis. We showed that Gsk3β is primarily expressed in the palatal epithelium, particularly in the medial edge epithelium overlapping with… CONTINUE READING
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