Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord.

@article{Kriks2005Gsh2IR,
  title={Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord.},
  author={Sonja Kriks and Guillermo M Lanuza and Rumiko Mizuguchi and Masato Nakafuku and Martyn Goulding},
  journal={Development},
  year={2005},
  volume={132 13},
  pages={2991-3002}
}
The molecular programs that specify progenitors in the dorsal spinal cord remain poorly defined. The homeodomain transcription factor Gsh2 is expressed in the progenitors of three dorsal interneuron subtypes, dI3, dI4 and dI5 neurons, whereas Gsh1 is only expressed in dI4 and dI5 progenitors. Mice lacking Gsh2 exhibit a selective loss of dI3 interneurons that is accompanied by an expansion of the dI2 progenitor domain. In Gsh2 mutant embryos, expression of the proneural bHLH protein Mash1 is… CONTINUE READING