Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1.

@article{Jbel2011Grx4MG,
  title={Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1.},
  author={Mehdi Jbel and Alexandre Mercier and Simon Labb{\'e}},
  journal={Eukaryotic cell},
  year={2011},
  volume={10 5},
  pages={629-45}
}
The expression of iron transport genes in Schizosaccharomyces pombe is controlled by the Fep1 transcription factor. When iron levels exceed those needed by the cells, Fep1 represses iron transport genes. In contrast, Fep1 is unable to bind chromatin under low-iron conditions, and that results in activation of genes involved in iron acquisition. Studies of fungi have revealed that monothiol glutaredoxins are required to inhibit iron-dependent transcription factors in response to high levels of… CONTINUE READING