Growth transformation of primary epithelial cells with a NPC-derived Epstein-Barr virus strain.

@article{Danve2001GrowthTO,
  title={Growth transformation of primary epithelial cells with a NPC-derived Epstein-Barr virus strain.},
  author={Christelle Danve and Gis{\`e}le Decaussin and Pierre Busson and Tadamasa Ooka},
  journal={Virology},
  year={2001},
  volume={288 2},
  pages={
          223-35
        }
}
The Epstein-Barr virus (EBV) is associated with two major human epithelial malignancies, where it is likely to play a role in the malignant phenotype: undifferentiated nasopharyngeal carcinoma (100% of cases) and gastric carcinomas (about 10% of cases). We and others have obtained growth transformation of monkey kidney primary epithelial cells by transfection of viral DNA, especially with the BARF1 gene of EBV (Wei et al., 1997). We now report that the same type of primary epithelial cells can… CONTINUE READING

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