Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator.

@article{Suganuma2002GrowthSO,
  title={Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator.},
  author={Tamaki Suganuma and Masahiro Kawabata and Tomoko Ohshima and Masa-aki Ikeda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 20},
  pages={13073-8}
}
The p300 and closely related cAMP response element binding protein (CREB)-binding protein (CBP) acetyltransferases function as global transcriptional coactivators and play important roles in a broad spectrum of biological processes, including cell proliferation and differentiation. A role of p300/CBP in tumor suppression has been proposed from the fact that these coactivators are targeted by viral oncoproteins and that biallelic mutations of p300 have been identified in carcinomas. Here, we… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…