Growth suppression by glucocorticoid therapy.

  title={Growth suppression by glucocorticoid therapy.},
  author={David B. Allen},
  journal={Endocrinology and metabolism clinics of North America},
  volume={25 3},
  • David B. Allen
  • Published 1996 in
    Endocrinology and metabolism clinics of North…
Glucocorticoids exert multiple growth-suppressing effects, interfering with endocrine (e.g., endogenous GH secretion) and metabolic (e.g., bone formation, nitrogen retention, collagen formation) processes essential for normal growth. Relatively small oral doses of daily exogenous GC, alternate-day oral GC therapy, and even IC are capable of slowing growth in some children. These growth-inhibiting and catabolic effects of GC can be variably counterbalanced by GH therapy. With regard to linear… CONTINUE READING

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