Growth-stimulating effects of recombinant human growth hormone in children with end-stage renal disease.

@article{Toenshoff1990GrowthstimulatingEO,
  title={Growth-stimulating effects of recombinant human growth hormone in children with end-stage renal disease.},
  author={Burkhard Toenshoff and O Mehis and Udo Heinrich and Werner Friedrich Blum and Michael B. Ranke and Alfred Schauer},
  journal={The Journal of pediatrics},
  year={1990},
  volume={116 4},
  pages={
          561-6
        }
}
Because patients with uremia have evidence for growth hormone resistance, we investigated whether this resistance can be overcome by administration of recombinant human growth hormone in supraphysiologic doses in children with severe uremia. Nine stunted children with end-stage renal disease (median age 5.8 years, median bone age 2.7 years) were treated with recombinant human growth hormone, 4 IU/m2/day subcutaneously, for a period of 1 year. Median height velocity was increased from 4.4 cm/yr… CONTINUE READING
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