Growth responses following a single intra-muscular hGH plasmid administration compared to daily injections of hGH in dwarf mice.

@article{Higuti2012GrowthRF,
  title={Growth responses following a single intra-muscular hGH plasmid administration compared to daily injections of hGH in dwarf mice.},
  author={Eliza Higuti and Cl{\'a}udia Regina Cecchi and N{\'e}lio A J Oliveira and Daniel Perez Vieira and Thomas Gryesten Jensen and Alexander A.L. Jorge and Paolo Bartolini and C. Peroni},
  journal={Current gene therapy},
  year={2012},
  volume={12 6},
  pages={
          437-43
        }
}
  • Eliza Higuti, Cláudia Regina Cecchi, +5 authors C. Peroni
  • Published in Current gene therapy 2012
  • Biology, Medicine
  • In previous work, sustained levels of circulating human growth hormone (hGH) and a highly significant weight increase were observed after electrotransfer of naked plasmid DNA (hGH-DNA) into the muscle of immunodeficient dwarf mice (lit/scid). In the present study, the efficacy of this in vivo gene therapy strategy is compared to daily injections (5 μg/twice a day) of recombinant hGH (r-hGH) protein, as assessed on the basis of several growth parameters. The slopes of the two growth curves were… CONTINUE READING

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