Growth problems in children with IBD

@article{Sanderson2014GrowthPI,
  title={Growth problems in children with IBD},
  author={Ian R Sanderson},
  journal={Nature Reviews Gastroenterology \&Hepatology},
  year={2014},
  volume={11},
  pages={601-610}
}
  • I. Sanderson
  • Published 24 June 2014
  • Medicine
  • Nature Reviews Gastroenterology &Hepatology
Crohn's disease in childhood causes linear growth retardation, which has a substantial effect on management of this disease. By contrast, growth is rarely a problem in children presenting with ulcerative colitis. Depending on how growth failure is defined, approximately one-third of children with Crohn's disease have growth retardation at diagnosis. Although corticosteroids can suppress growth, decreased height at diagnosis demonstrates that this finding is a consequence of the disease and not… 

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References

SHOWING 1-10 OF 149 REFERENCES

Growth retardation in pediatric Crohn's disease: Pathogenesis and interventions

This review summarizes current knowledge as well as gaps in the understanding of the mechanisms involved and the usefulness of the different treatment modalities in promoting growth in CD patients.

Guidelines for the management of growth failure in childhood inflammatory bowel disease.

A systematic review of publications was carried out to identify the best available evidence for managing growth failure in children with IBD, finding sufficient data to allow practical, evidence-based where possible, management guidelines to be formulated.

Effect of administered human growth hormone on growth retardation in inflammatory bowel disease

It appears that the youngsters with IBD may have a relative end-organ resistance to the metabolic and growth-promoting effects of HGH and that their growth problems are not related to hypopituitarism.

Interventions for growth failure in childhood Crohn's disease.

The need for large, multi centre studies of the different treatment options in paediatric Crohn's disease and the importance of standardised measurements of growth, such as height velocity standard deviations scores and height standard deviation scores as outcome measures are highlighted.

The Role of Pro-Inflammatory Cytokines in Inflammatory Bowel Disease Growth Retardation

Clinically well-controlled clinical studies of the respective effect of nutritional support, immunomodulatory therapy, biological agents and growth and puberty promoting agents on managing faltering growth in childhood IBD require further attention.

TNF Promoter Polymorphisms and Modulation of Growth Retardation and Disease Severity in Pediatric Crohn's Disease

Polymorphisms in the TNF-alpha promoter may independently modulate growth and disease severity in pediatric onset Crohn's disease, and the effect of these polymorphisms does not appear to be mediated via weight loss, and is relatively modest.

Effect of Recombinant Growth Hormone Treatment on Children With Crohn's Disease and Short Stature: A Pilot Study

GH treatment at the dose given did not stimulate growth in children with Crohn's disease and short stature, and whether or not GH plus nutritional therapy would be effective in promoting sustained catch‐up growth remains to be determined.

Longitudinal Growth in Children and Adolescents with Inflammatory Bowel Disease

It is indicated that, although final height was significantly reduced in children with Crohn's disease, delayed puberty reduced the negative effects on permanent adult height, to a certain extent compensating for the period of poor growth earlier in life.
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