Growth phase‐dependent changes in the subcellular localization of pre‐B‐cell colony‐enhancing factor 1

@article{Kitani2003GrowthPC,
  title={Growth phase‐dependent changes in the subcellular localization of pre‐B‐cell colony‐enhancing factor
1},
  author={Takako Kitani and Sachiko Okuno and Hitoshi Fujisawa},
  journal={FEBS Letters},
  year={2003},
  volume={544}
}
A cDNA encoding the homolog of the human pre‐B‐cell colony‐enhancing factor (PBEF), a cytokine‐like secreted protein, was isolated from a rat cDNA library. This protein existed in both the cytoplasm and nucleus of the cells, and the amount was higher in the cytoplasm than in the nucleus of proliferating PC‐12 and Swiss 3T3 cells but higher in the nucleus than in the cytoplasm of the PC‐12 cells treated with nerve growth factor and the 3T3 cells grown to a confluent state. Thus, the so‐called… Expand
Pre‐B cell colony‐enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity
TLDR
A review summarizes the admittedly incomplete body of emerging knowledge about a remarkable new mediator of innate immunity about Pre‐B cell colony‐enhancing factor. Expand
Pre–B-Cell Colony–Enhancing Factor Regulates NAD+-Dependent Protein Deacetylase Activity and Promotes Vascular Smooth Muscle Cell Maturation
TLDR
Findings identify PBEF as a regulator of NAD+-dependent reactions in SMCs, reactions that promote, among other potential processes, the acquisition of a mature SMC phenotype. Expand
Pre-B-cell colony-enhancing factor is a secreted cytokine-like protein from the human amniotic epithelium.
TLDR
Although it had no chemotaxic effects, pre-B-cell colony-enhancing factor was antiapoptotic for both amniotic epithelial cells and fibroblasts and may protect these cells against apoptosis that is induced by chronic distension, labor, or infection. Expand
Pre-B cell colony-enhancing factor in lower vertebrates: first evidence of this cytokine being involved in antioxidant activity by reconstruction of a novel NAD salvage pathway in E. coli.
TLDR
This is the first report about vertebrate pre-B cell colony-enhancing factor acting as a nicotinamide phosphoribosyltransferase to reconstruct a pyridine nucleotide cycle III pathway in E. coli and playing an important role in antioxidant stress by up-regulation of NAD biosynthesis. Expand
Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions.
TLDR
The purpose of this review is to summarize the recent advances in PBEF research. Expand
Visfatin/pre-B-cell colony-enhancing factor: A protein with various suggested functions
TLDR
This review summarizes the current knowledge of the various functions of PBEF/visfatin towards involvements in pathophysiology of several diseases. Expand
Nicotinamide Phosphoribosyl Transferase/Pre-B Cell Colony-Enhancing Factor/Visfatin Is Required for Lymphocyte Development and Cellular Resistance to Genotoxic Stress1
TLDR
It is unequivocally demonstrated that the ability of the Nampt to regulate cell viability during genotoxic stress requires its enzymatic activity, and it may confer to cells of the immune system the ability to survive during stressful situations such as inflammation. Expand
Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis.
TLDR
PBEF is identified as a novel inflammatory cytokine that plays a requisite role in the delayed neutrophil apoptosis of clinical and experimental sepsis and is also upregulated in neutrophils by IL-1beta and functions as an inhibitor of apoptosis in response to a variety of inflammatory stimuli. Expand
Pre-B Cell Colony-enhancing Factor (PBEF) Promotes Neutrophil Inflammatory Function through Enzymatic and Non-enzymatic Mechanisms
Pre-B Cell Colony-Enhancing Factor (PBEF) is a cytokine-like molecule that functions as a nicotinamide phosphoribosyl transferase (Nampt) in a salvage pathway of NAD biosynthesis. PBEF hasExpand
Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866.
TLDR
The crystal structures of the complexes with either NMN or FK-866 show that the enzymatic active site of visfatin is optimized for Nicotinamide binding and that the nicotinamide-binding site is important for inhibition by FK -866, raising the intriguing possibility that the glucose metabolism and the NAD biosynthesis are linked by visFatin. Expand
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