Growth pattern of tumor xenografts in Wistar rats after treatment with cyclophosphamide, total lymphoid irradiation and/or cyclosporin A.

@article{Hoogenhout1983GrowthPO,
  title={Growth pattern of tumor xenografts in Wistar rats after treatment with cyclophosphamide, total lymphoid irradiation and/or cyclosporin A.},
  author={Jaap Hoogenhout and Ihab Kazem and C. R. Jerusalem and J. A. J. M. Bakkeren and Jannie de Jong and Henk B. Kal and P J J VAN MUNSTER},
  journal={International journal of radiation oncology, biology, physics},
  year={1983},
  volume={9 6},
  pages={871-9}
}
Wistar rats treated with cyclophosphamide, total lymphoid irradiation (TLI), and/or cyclosporin A (CSA) develop a state of immune suppression permitting the growth of tumor xenografts. Experiments were carried out on this newly developed model to investigate the growth patterns of a mouse osteosarcoma and a human colon adenocarcinoma. The combination of cyclophosphamide and CSA permitted a limited period of growth of the mouse osteosarcoma with a tumor take rate of 66%. No takes were observed… CONTINUE READING