Growth of primary human acute lymphoblastic and myeloblastic leukemia in SCID mice.

@article{Lord1994GrowthOP,
  title={Growth of primary human acute lymphoblastic and myeloblastic leukemia in SCID mice.},
  author={Corinne De Lord and R. D. Clutterbuck and Ray L Powles and Ricardo M Morilla and A. Hanby and Jenny C Titley and Toon Min and J L Millar},
  journal={Leukemia & lymphoma},
  year={1994},
  volume={16 1-2},
  pages={157-65}
}
The in vivo growth of 8 human primary acute lymphoblastic (ALL) and 17 primary acute myeloblastic (AML) cell populations was investigated in severe combined immunodeficient (SCID) mice. Bone marrow (BM) or peripheral blood (PB) samples, either fresh or cryopreserved, were implanted i.v. into irradiated SCID mice. The cells from 5/8 patients with ALL resulted in engraftment with systemic proliferation and dissemination leading to morbidity and mortality of the animals within 12-18 weeks from… CONTINUE READING