Growth of malignant oral epithelial stem cells after seeding into organotypical cultures of normal mucosa.

Abstract

BACKGROUND Oral squamous cell carcinoma (OSCC) is associated both with the local expansion of clones of malignant cells and with their further migration to regional and distant sites. The interactions that occur between normal and malignant cells during these events are not well modelled by standard culture conditions, but organotypical cultures, in which… (More)

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