Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature dependent.

@article{Radna1989GrowthOI,
  title={Growth of immortal simian virus 40 tsA-transformed human fibroblasts is temperature dependent.},
  author={R L Radna and Y Caton and Krishna Kumar Jha and P Kaplan and Geng Li and Frank Traganos and Harvey L. Ozer},
  journal={Molecular and cellular biology},
  year={1989},
  volume={9 7},
  pages={3093-6}
}
Simian virus 40 (SV40)-mediated transformation of human fibroblasts offers an experimental system for studying both carcinogenesis and cellular aging, since such transformants show the typical features of altered cellular growth but still have a limited life span in culture and undergo senescence. We have previously demonstrated (D. S. Neufeld, S. Ripley, A. Henderson, and H. L. Ozer, Mol. Cell. Biol. 7:2794-2802, 1987) that transformants generated with origin-defective mutants of SV40 show an… CONTINUE READING

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