Growth of hippocampal mossy fibers: a lesion and coculture study of organotypic slice cultures.

@article{Zimmer1987GrowthOH,
  title={Growth of hippocampal mossy fibers: a lesion and coculture study of organotypic slice cultures.},
  author={Jens Zimmer and Beat H. G{\"a}hwiler},
  journal={The Journal of comparative neurology},
  year={1987},
  volume={264 1},
  pages={1-13}
}
In hippocampal slice cultures, the mossy fibers from the dentate granule cells project as normally to cells in the dentate hilus (CA4) and the hippocampal CA3 pyramidal cells. After lesions in vivo and intracerebral transplantation, the mossy fibers can alter their normal distribution within CA3 and even contact CA1 pyramidal cells. The present study examined whether similar changes could be induced in the more simple, virtual two-dimensionally organized slice cultures. For this purpose slices… CONTINUE READING