Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach.

@article{Loessner2013GrowthOC,
  title={Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach.},
  author={Daniela Loessner and Jennifer A. Flegg and Helen M. Byrne and Judith A. Clements and Dietmar Werner Hutmacher},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2013},
  volume={5 3},
  pages={
          597-605
        }
}
A critical step in the dissemination of ovarian cancer is the formation of multicellular spheroids from cells shed from the primary tumour. The objectives of this study were to apply bioengineered three-dimensional (3D) microenvironments for culturing ovarian cancer spheroids in vitro and simultaneously to build on a mathematical model describing the growth of multicellular spheroids in these biomimetic matrices. Cancer cells derived from human epithelial ovarian carcinoma were embedded within… 
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50 Citations

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TLDR
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TLDR
A mathematical model able to describe in a case-specific way as well as to predict in a probabilistic way the growth and the real invasion pattern of multicellular tumour spheroids (in vitro model of an avascular microtumour) immersed in a collagen matrix is built.
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