Growth of an RNA virus in single cells reveals a broad fitness distribution.


Genetic and environmental factors will influence the growth of an RNA virus, but their relative contributions are challenging to resolve because standard culture methods mask how virus particles interact with individual host cells. Here, single particles of vesicular stomatitis virus, a prototype RNA virus, were used to infect individual BHK cells. Infected… (More)
DOI: 10.1016/j.virol.2008.10.031


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