Growth of Plasmodium falciparum in human erythrocytes containing abnormal membrane proteins.

@article{Schulman1990GrowthOP,
  title={Growth of Plasmodium falciparum in human erythrocytes containing abnormal membrane proteins.},
  author={Seymour Schulman and Eugene F. Roth and Behling Cheng and Anne C Rybicki and Ira I. Sussman and M Wong and Weixun Wang and Helen M. Ranney and Ronald L. Nagel and Russell S Schwartz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 18},
  pages={7339-43}
}
To evaluate the role of erythrocyte (RBC) membrane proteins in the invasion and maturation of Plasmodium falciparum, we have studied, in culture, abnormal RBCs containing quantitative or qualitative membrane protein defects. These defects included hereditary spherocytosis (HS) due to decreases in the content of spectrin [HS(Sp+)], hereditary elliptocytosis (HE) due to protein 4.1 deficiency [HE(4.1(0))], HE due to a spectrin alpha I domain structural variant that results in increased content of… CONTINUE READING