Growth of P511 mastocytoma cells in BALB/c mouse brain elicits CTL response without tumor elimination: a new tumor model for regional central nervous system immunity.

@article{Gordon1997GrowthOP,
  title={Growth of P511 mastocytoma cells in BALB/c mouse brain elicits CTL response without tumor elimination: a new tumor model for regional central nervous system immunity.},
  author={Leslie B Gordon and Scott C. Nolan and Helen F. Cserr and Paul Mark Knopf and Christine J. Harling-Berg},
  journal={Journal of immunology},
  year={1997},
  volume={159 5},
  pages={2399-408}
}
We have developed a murine model to explore the tumor-specific CTL response in the immune-privileged central nervous system using P511 mastocytoma cells. Three strains with varying degrees of histocompatibility to P511 cells (CD-1, allogeneic; BALB/c, minor histoincompatible; DBA/2, syngeneic) received tumor cells (10(4)) into the putamen 7 days after cannula implantation, when the blood-brain barrier was functionally intact. Without exception, tumor formed reproducibly by day 7 in all strains… CONTINUE READING