Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny

@inproceedings{Huang2018GrowthOM,
  title={Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny},
  author={Lu Huang and Evgeniya V Nazarova and Shumin Tan and Yancheng Liu and David G Russell},
  booktitle={The Journal of experimental medicine},
  year={2018}
}
To understand how infection by Mycobacterium tuberculosis (Mtb) is modulated by host cell phenotype, we characterized those host phagocytes that controlled or supported bacterial growth during early infection, focusing on the ontologically distinct alveolar macrophage (AM) and interstitial macrophage (IM) lineages. Using fluorescent Mtb reporter strains, we found that bacilli in AM exhibited lower stress and higher bacterial replication than those in IM. Interestingly, depletion of AM reduced… CONTINUE READING

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