Growth of E. coli on formate and methanol via the reductive glycine pathway

  title={Growth of E. coli on formate and methanol via the reductive glycine pathway},
  author={Seohyoung Kim and Steffen N. Lindner and Selçuk Aslan and Oren Yishai and Sebastian Wenk and Karin Schann and Arren Bar‐Even},
  journal={Nature Chemical Biology},
  pages={538 - 545}
Engineering a biotechnological microorganism for growth on one-carbon intermediates, produced from the abiotic activation of CO2, is a key synthetic biology step towards the valorization of this greenhouse gas to commodity chemicals. Here we redesign the central carbon metabolism of the model bacterium Escherichia coli for growth on one-carbon compounds using the reductive glycine pathway. Sequential genomic introduction of the four metabolic modules of the synthetic pathway resulted in a… 

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