Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line.

@article{Heinemann1996GrowthOC,
  title={Growth of Chlamydia pneumoniae induces cytokine production and expression of CD14 in a human monocytic cell line.},
  author={Markus Heinemann and Milorat Susa and Ulrike Simnacher and Reinhard Marre and Andreas Essig},
  journal={Infection and immunity},
  year={1996},
  volume={64 11},
  pages={4872-5}
}
Chlamydia pneumoniae was able to survive and to multiply in the human monocytic cell line Mono Mac 6. Growth of C. pneumoniae induced production of tumor necrosis factor alpha, interleukin 1beta, and interleukin 6, as well as up-regulation of the CD14 molecule in a time-dependent manner. Infection of monocytic cells and a proinflammatory cytokine response may be important in C. pneumoniae pathogenesis.