Growth of Candida albicans hyphae

@article{Sudbery2011GrowthOC,
  title={Growth of Candida albicans hyphae},
  author={Peter E. Sudbery},
  journal={Nature Reviews Microbiology},
  year={2011},
  volume={9},
  pages={737-748}
}
  • P. Sudbery
  • Published 1 October 2011
  • Biology, Medicine
  • Nature Reviews Microbiology
The fungus Candida albicans is often a benign member of the mucosal flora; however, it commonly causes mucosal disease with substantial morbidity and in vulnerable patients it causes life-threatening bloodstream infections. A striking feature of its biology is its ability to grow in yeast, pseudohyphal and hyphal forms. The hyphal form has an important role in causing disease by invading epithelial cells and causing tissue damage. This Review describes our current understanding of the network… Expand
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References

SHOWING 1-10 OF 159 REFERENCES
Genetics of Candida albicans, a diploid human fungal pathogen.
TLDR
Recent developments in population genetics, the mating process, and gene disruption technology that are providing much needed experimental insights into the biology of C. albicans are described. Expand
Modulation of Morphogenesis in Candida albicans by Various Small Molecules
TLDR
This minireview takes a look at molecules that modulate morphogenesis in this pathogenic yeast and discusses whether or not modulating morphogenesis constitutes a strategy to treat Candida infections. Expand
The distinct morphogenic states of Candida albicans.
TLDR
It is argued that studies on "filamentous forms" should always include a formal analysis to determine whether the cells are hyphae or pseudohyphae and some simple experimental criteria that can be applied to achieve this are suggested. Expand
Adaptation to environmental pH in Candida albicans and its relation to pathogenesis
  • D. Davis
  • Biology, Medicine
  • Current Genetics
  • 2003
TLDR
The RIM101/pacC pathway, which governs pH responses and differentiation, has been the focus of study in both Saccharomyces cerevisiae and Aspergillus nidulans and has been identified in C. albicans. Expand
Pseudomonas-Candida Interactions: An Ecological Role for Virulence Factors
TLDR
It is proposed that many virulence factors studied in the context of human infection may also have a role in bacterial-fungal interactions. Expand
Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.
TLDR
A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases, representing a paradigm for microbial adhesion that implicates essential host enzymes. Expand
A Pseudomonas aeruginosa quorum‐sensing molecule influences Candida albicans morphology
TLDR
Candida albicans morphology is significantly affected by the presence of Pseudomonas aeruginosa, another opportunistic pathogen, and filamentation was suppressed by 200 µM 3‐oxo‐C12 homoserine lactone. Expand
Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes
TLDR
This study uses scanning electron and fluorescence microscopy, adhesion, invasion and damage assays, fungal mutants and a set of fungal and host cell inhibitors to investigate the interactions of C. albicans with oral epithelial cells and enterocytes, demonstrating that epithelial Cells differ in their susceptibility to the fungus. Expand
Morphogenesis in Candida albicans.
  • F. Odds
  • Biology, Medicine
  • Critical reviews in microbiology
  • 1985
This review will survey environmental controls on the morphology of Candida albicans, describe the cellular and ultrastructural events associated with morphological transitions in this fungus, andExpand
UME6, a novel filament-specific regulator of Candida albicans hyphal extension and virulence.
TLDR
The results suggest that hyphal extension is controlled by a specific transcriptional regulatory mechanism and is correlated with the maintenance of high-level expression of genes in the C. albicans filamentous growth program. Expand
...
1
2
3
4
5
...