Growth negatively impacts the life span of mammals

@article{Rollo2002GrowthNI,
  title={Growth negatively impacts the life span of mammals},
  author={Callum Rollo},
  journal={Evolution \& Development},
  year={2002},
  volume={4}
}
  • C. Rollo
  • Published 2002
  • Environmental Science
  • Evolution & Development
SUMMARY A negative intraspecific relationship between growth and longevity was proposed in the early 20th century. Indeed, stunting the growth of rodents by restricting their food dramatically extended life span. Subsequently, however, the hypothesis that growth exacerbates aging rates fell into disfavor. Contributing to this was (a) the establishment of a positive relationship between body size and longevity interspecifically, (b) purported antiaging impacts of growth hormone, and (c) the fact… 
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References

SHOWING 1-10 OF 92 REFERENCES
Differential longevity in mouse stocks selected for early life growth trajectory.
TLDR
The data provide support for the hypothesis that genetic factors that influence early life growth trajectories can have a strong influence on life span, and size-selected mice provide useful tools for analysis of the genetic Factors that influence life history parameters, including maturation and aging rates.
Genetic relation of life span to metabolic rate for inbred mouse strains and their hybrids.
TLDR
The data suggest the existence of a longevity factor dependent on the partition of energy between the phasic metabolism of activity and the continuous maintenance metabolism, and a new metabolism variable, the energy partition coefficient, has a parabolic relation to body weight.
Delayed aging in Ames dwarf mice. Relationships to endocrine function and body size.
  • A. Bartke
  • Biology
    Results and problems in cell differentiation
  • 2000
TLDR
Evidence for the existence of LAGs in yeast, C. elegans, and Drosophila and the effects of mutations at these loci are described, and a new term, longevity assurance genes (LAGs), was coined to describe genes involved in the control of the life span.
Accelerated aging of giant transgenic mice is associated with elevated free radical processes
TLDR
The pattern of SOR and LP levels across kinds of mice and diets supported a free radical interpretation of aging and suggested that energy supply (protein or sugar) may impact longevity.
Insulin Exposure and Unifying Aging
TLDR
Declining mitochondrial state 3 aging energy production status is easily and safely reversible with probable consequences of greatly postponing the decline in overall ‘reserve capacity’ which may also improve insulin: growth hormone balance and result in lower overall growth factor exposure and consequent longer healthy life of a potentially greater magnitude increase in life spans than that seen in calorie-restricted animals.
Kleemeier award lecture: are there genes for aging?
  • R. Miller
  • Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 1999
TLDR
It is shown that aging can be affected by genetic variations within a species, but identification of genetic differences that discriminate long-lived from short-lived species will require a combination of genetic and physiological analyses.
Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals.
  • W. Sonntag, C. Lynch, A. Khan
  • Biology, Medicine
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 1999
TLDR
It is proposed that endocrine compensatory mechanisms induced by moderate caloric restriction decrease the stimulus for cellular replication, resulting in a decline in pathologies and increased life span observed in aged ad libitum-fed animals.
Aged-rodent models of long-term growth hormone therapy: lack of deleterious effect on longevity.
TLDR
It is concluded that long-term low-dose GH therapy that includes doses in the range that is given to humans in clinical trials in GH deficiency and to revert age-related physiologic declines has no overt deleterious effects on longevity and pathology in aged rodents.
Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.
TLDR
The effects of loss of GH signaling on growth and aging in a mouse model for Laron Syndrome in which the GHR/BP gene has been disrupted were studied and it was observed that mice homozygous for the disruption (-/-) were significantly smaller than normal wild-type (+/+) mice and lived significantly longer than +/+ and +/- mice.
...
1
2
3
4
5
...