Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines.

  title={Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines.},
  author={Bohuslav Melichar and Gabriella Ferrandina and Claire F. Verschraegen and Amy Loercher and James L Abbruzzese and R. S. Freedman},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={4 12},
Epithelial ovarian cancer is a major cause of cancer-related mortality in women, making the search for new treatment modalities essential. Sodium phenylacetate (NaPa), a phenylalanine derivative, has been shown to induce cytostasis and differentiation by inhibiting protein isoprenylation. Similar effects have been observed with phenylbutyrate, a phenylacetate congener. We examined in parallel the growth inhibitory activity against human ovarian carcinoma cell lines of phenylacetate… CONTINUE READING
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Interferon -y and tumor necrosis factora treatment of ex vivo human carcinoma cells potentiates their interaction with allogeneic lymphocytes

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