Growth-inhibitory effect of a high glucose concentration on osteoblast-like cells.

@article{Terada1998GrowthinhibitoryEO,
  title={Growth-inhibitory effect of a high glucose concentration on osteoblast-like cells.},
  author={Masaru Terada and Masaaki Inaba and Yoshihisa Yano and Tadayoshi Hasuma and Yoshio Nishizawa and Hirotoshi Morii and Shuzo Otani},
  journal={Bone},
  year={1998},
  volume={22 1},
  pages={
          17-23
        }
}
Impaired bone formation resulting from a decline of osteoblast activity has been implicated in the pathogenesis of diabetic osteopenia. We examined the effects of high glucose concentration alone, independent of insulin deficiency, on the growth of a human osteoblast-like cell line (MG-63). Sustained exposure to high glucose for 7 days inhibited cell growth in a concentration-dependent manner up to 49.5 mmol/L, as compared with cells cultured with a normal glucose concentration (5.5 mmol/L) or… CONTINUE READING
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