Corpus ID: 39533723

Growth inhibition of tumour cells by a liposome-encapsulated, mycolic acid-containing glycolipid, trehalose 2,3,6'-trimycolate.

@article{Ohtsubo1991GrowthIO,
  title={Growth inhibition of tumour cells by a liposome-encapsulated, mycolic acid-containing glycolipid, trehalose 2,3,6'-trimycolate.},
  author={Y. Ohtsubo and M. Furukawa and Takahito Imagawa and N. Sugimoto and M. Ikutoh and S. Nakatsugi and Y. Katoh and S. Shinka and Y. Dohi},
  journal={Immunology},
  year={1991},
  volume={74 3},
  pages={
          497-503
        }
}
  • Y. Ohtsubo, M. Furukawa, +6 authors Y. Dohi
  • Published 1991
  • Biology, Medicine
  • Immunology
  • In vivo growth of syngeneic tumour cells in the peritoneal cavity was strongly inhibited by intraperitoneal injection of a liposome-encapsulated, mycolic acid-containing glycolipid, trehalose 2,3,6'-trimycolate (TTM), derived from a non-pathogenic, acid-fast bacterium. Gordona aurantiaca. Peritoneal macrophages from mice after this treatment lysed tumour cells in vitro at a low effector/target ratio, and their culture supernatant inhibited tumour cell growth. The supernatant inhibited growth of… CONTINUE READING
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