Growth inhibition of murine mammary carcinoma by monoclonal IgE antibodies specific for the mammary tumor virus

@article{Nagy1991GrowthIO,
  title={Growth inhibition of murine mammary carcinoma by monoclonal IgE antibodies specific for the mammary tumor virus},
  author={{\'E}va {\'E} Nagy and Istvan Berczi and Alec H. Sehon},
  journal={Cancer Immunology, Immunotherapy},
  year={1991},
  volume={34},
  pages={63-69}
}
Two IgE-producing hybridomas were established from spleen cells of Balb/c mice, which had been immunized with mouse mammary tumor virus (MMTV). These IgE monoclonal antibodies (mAbs) reacted specifically with the major envelope glycoprotein (gp36) of MMTV, as established by the immunoblot assay and by passive cutaneous anaphylaxis. The effect of the IgE mAbs (produced by clone A8) on the growth of the MMTV-secreting mammary adenocarcinoma H2712 was investigated in syngeneic C3H/HeJ mice. The… CONTINUE READING

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