Growth inhibition of liver metastases by the anti-angiogenic drug TNP-470.

  title={Growth inhibition of liver metastases by the anti-angiogenic drug TNP-470.},
  author={Pascal A Gervaz and Beatrix Scholl and Vivianne Padrun and Michel Gillet},
  volume={20 2},
OBJECTIVE This study was undertaken in order to assess the efficacy of a potent angiogenesis inhibitor, TNP-470, on tumor growth in a syngeneic rodent model of liver metastases from colorectal cancer. BACKGROUND New blood vessel formation is a prerequisite for primary and metastatic tumor growth. TNP-470, a synthetic derivative of fumagillin when subcutaneously transplanted into nude mice, inhibits endothelial cell proliferation and migration, as well as the growth of various human cancers… CONTINUE READING


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