Growth inhibition of human ovarian cancers by cytotoxic analogues of luteinizing hormone-releasing hormone.

@article{Miyazaki1997GrowthIO,
  title={Growth inhibition of human ovarian cancers by cytotoxic analogues of luteinizing hormone-releasing hormone.},
  author={Masaru Miyazaki and Attila Nagy and Andrew V Schally and N Lamharzi and G{\'a}bor Halmos and Karoly Szepesh{\'a}zi and Kate Groot and Patricia Armatis},
  journal={Journal of the National Cancer Institute},
  year={1997},
  volume={89 23},
  pages={1803-9}
}
BACKGROUND Receptors for luteinizing hormone-releasing hormone (LH-RH) are found in nearly 80% of human ovarian cancers. The chemotherapeutic agent doxorubicin can be linked to [D-lysine6]LH-RH to form a cytotoxic analogue (AN-152) that may have greater specificity for tumor cells. This study was conducted to investigate the effects of AN-152 on the growth of LH-RH receptor-positive OV-1063 human epithelial ovarian cancers. METHODS Nude mice bearing human ovarian tumors, OV-1063 or UCI-107… CONTINUE READING

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