Growth inhibition of human lung adenocarcinoma cells by antibodies against epidermal growth factor receptor and by ganglioside GM3: involvement of receptor-directed protein tyrosine phosphatase(s).

@article{Pestana1997GrowthIO,
  title={Growth inhibition of human lung adenocarcinoma cells by antibodies against epidermal growth factor receptor and by ganglioside GM3: involvement of receptor-directed protein tyrosine phosphatase(s).},
  author={E. Suarez Pestana and Udo Greiser and Belinda S{\'a}nchez and Luis E. Fern{\'a}ndez and Agust{\'i}n Lage and Rolando P{\'e}rez and Frank D. B{\"o}hmer},
  journal={British Journal of Cancer},
  year={1997},
  volume={75},
  pages={213 - 220}
}
Growth of the EGF receptor-expressing non-small-cell lung carcinoma cell line H125 seems to be at least partially driven by autocrine activation of the resident EGF receptors. Thus, the possibility of an EGF receptor-directed antiproliferative treatment was investigated in vitro using a monoclonal antibody (alpha EGFR ior egf/r3) against the human EGF receptor and gangliosides which are known to possess antiproliferative and anti-tyrosine kinase activity. The moderate growth-inhibitory effect… CONTINUE READING

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