Corpus ID: 31406732

Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.

@article{Rich1958GrowthIO,
  title={Growth inhibition of a human tumor cell strain by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine; reversal studies.},
  author={M. Rich and J. L. Bolaffi and J. Knoll and L. Cheong and M. L. Eidinoff},
  journal={Cancer research},
  year={1958},
  volume={18 6},
  pages={
          730-5
        }
}
Summary The effects of 5-fluorouracil (FU), 5-fluorouradine (FUR), and 5-fluoro-2′-deoxyuridine (FUDR). on the growth of H.Ep. #1 human cell strain in a semisynthetic medium have been studied. FU, FUR, and FUDR produced complete inhibition of growth at 1.0, 0.01, and 0.01 µg/ml., respectively (8 × 10-6, 0.4 × 10-7, and 0.4 × 10-7m). The complete growth inhibition by FUDR at 4 × 10-7m is reversed by an approximately equivalent concentration of thymidine. The extent of reversal is independent of… Expand
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