Growth inhibition of Sporomusa ovata by incorporation of benzimidazole bases into cobamides.

@article{Mok2013GrowthIO,
  title={Growth inhibition of Sporomusa ovata by incorporation of benzimidazole bases into cobamides.},
  author={Kenny C Mok and Michiko E Taga},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 9},
  pages={1902-11}
}
Phenolyl cobamides are unique members of a class of cobalt-containing cofactors that includes vitamin B12 (cobalamin). Cobamide cofactors facilitate diverse reactions in prokaryotes and eukaryotes. Phenolyl cobamides are structurally and chemically distinct from the more commonly used benzimidazolyl cobamides such as cobalamin, as the lower axial ligand is a phenolic group rather than a benzimidazole. The functional significance of this difference is not well understood. Here we show that in… CONTINUE READING

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