Growth inhibition of Clostridium thermocellum by carboxylic acids: A mechanism based on uncoupling by weak acids

@article{Herrero2004GrowthIO,
  title={Growth inhibition of Clostridium thermocellum by carboxylic acids: A mechanism based on uncoupling by weak acids},
  author={Alejandro A. Herrero and Reinaldo F. Gomez and Brad Snedecor and Cynthia J. Tolman and Mary F. Roberts},
  journal={Applied Microbiology and Biotechnology},
  year={2004},
  volume={22},
  pages={53-62}
}
The inhibition of Clostridium thermocellum strains by acetate and other organic acids (propionate, butyrate) can be explained by a model based on the chemiosmotic theory and uncoupler action. It is proposed that the charged permeant species in the process of anion exclusion is the dimer HA - 2 . Evidence for this mechanisms is provided by 31P-NMR studies of whole cells and cell extracts. 
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