Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone.

@article{Nam2007GrowthIA,
  title={Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone.},
  author={Dong-Ho Nam and Sabarish Ramachandran and Dae-kyu Song and Kun Young Kwon and D Jeon and So-Jin Shin and Sang Hoon Kwon and S Cha and Insoo Bae and C -H Cho},
  journal={Molecular human reproduction},
  year={2007},
  volume={13 11},
  pages={829-36}
}
The nuclear receptors PPARs (peroxisome proliferator-activated receptors) are transcription factors that play important roles in multiple disease conditions. The activation of PPARs by specific ligands is associated with growth suppression of several different types of human cancer, but the molecular mechanism responsible for this growth suppressive effect remains elusive. The aim of this study was to determine the distribution of PPARgamma protein/mRNA expression in uterine leiomyomas and to… CONTINUE READING