Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane.

@article{Fimognari2002GrowthIC,
  title={Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane.},
  author={Carmela Fimognari and Michael N{\"u}sse and Rossano Cesari and Renato Iori and G. Cantelli-forti and Patrizia Hrelia},
  journal={Carcinogenesis},
  year={2002},
  volume={23 4},
  pages={581-6}
}
Glucosinolates (GL) can inhibit, retard or reverse experimental multistage carcinogenesis. When brassica plant tissue is broken, GLs are hydrolyzed by the endogenous enzyme myrosinase (Myr), releasing many products including isothiocyanates (ITC). Synthetic ITCs like sulforaphane exert chemopreventive effects against chemically induced tumors in animals, modulating enzymes required for carcinogens' activation/detoxification and/or the induction of cell-cycle arrest and apoptosis in tumor cell… CONTINUE READING

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