Growth hormones reverse desensitization of P2Y(2) receptors in rat mesangial cells.

@article{Gutirrez2000GrowthHR,
  title={Growth hormones reverse desensitization of P2Y(2) receptors in rat mesangial cells.},
  author={Antonio Manuel Guti{\'e}rrez and Xiao Liang Lou and A Erik and Gunnar Persson and Avi Ring},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={270 2},
  pages={594-9}
}
Rat glomerular mesangial cells (GMC) express P2Y(2) purinoceptors and respond to nucleotide stimuli with a transient increase in the cytosolic Ca(2+) concentration and the receptors desensitize upon repeated stimulation with nucleotide. We demonstrate that there is a cross-talk from the signaling of tyrosine kinase to P2Y(2) receptors. For most cells repeated applications of ATP completely abolished the response, as did activation of PKC with 500 nM PMA. In contrast, preincubation with the PKC… CONTINUE READING