Growth hormone versus placebo treatment for one year in growth hormone deficient adults: increase in exercise capacity and normalization of body composition.

@article{Jrgensen1996GrowthHV,
  title={Growth hormone versus placebo treatment for one year in growth hormone deficient adults: increase in exercise capacity and normalization of body composition.},
  author={Jens Otto Lunde J\orgensen and Nina Vahl and Torben B. Hansen and Leif Thuesen and Claus Hagen and Jens Sandahl Christiansen},
  journal={Clinical endocrinology},
  year={1996},
  volume={45 6},
  pages={681-8}
}
OBJECTIVE Studies with GH substitution in GH-deficient (GHD) adults lasting more than 6 months have so far been uncontrolled. End-points such as physical fitness and body composition may be subject to a considerable placebo effect which weakens the validity of open studies. We therefore tested GH (2 IU/m2 per day) versus placebo treatment for 12 months. DESIGN Twenty-nine patients (mean age 45.5 +/- 2.0 years) with adult-onset GHD were studied in a double-blind, parallel design. Measurements… CONTINUE READING

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