Growth hormone treatment of adults with Prader-Willi syndrome and growth hormone deficiency improves lean body mass, fractional body fat, and serum triiodothyronine without glucose impairment: results from the United States multicenter trial.

@article{Mogul2008GrowthHT,
  title={Growth hormone treatment of adults with Prader-Willi syndrome and growth hormone deficiency improves lean body mass, fractional body fat, and serum triiodothyronine without glucose impairment: results from the United States multicenter trial.},
  author={Harriette R. Mogul and Phillip D. K. Lee and Barbara Y. Whitman and William B Zipf and Michael Frey and Susan Myers and Mindy Cahan and Belinda Pinyerd and A. Louis Southren},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 4},
  pages={1238-45}
}
CONTEXT GH replacement in Prader-Willi syndrome (PWS) children has well-defined benefits and risks and is used extensively worldwide. Its use in PWS adults has been limited by documentation of benefits and risks, as determined by larger multisite studies. OBJECTIVES Our objective was to evaluate the effectiveness and safety of GH in GH-deficient genotype-positive PWS adults. DESIGN We conducted a 12-month open-label multicenter trial with 6-month dose-optimization and 6-month stable… CONTINUE READING

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