Growth hormone treatment enhances the functional recovery of sciatic nerves after transection and repair.

Abstract

INTRODUCTION Although nerves can spontaneously regenerate in the peripheral nervous system without treatment, functional recovery is generally poor, and thus there is a need for strategies to improve nerve regeneration. METHODS The left sciatic nerve of adult rats was transected and immediately repaired by epineurial sutures. Rats were then assigned to one of two experimental groups treated with either growth hormone (GH) or saline for 8 weeks. Sciatic nerve regeneration was estimated by histological evaluation, nerve conduction tests, and rotarod and treadmill performance. RESULTS GH-treated rats showed increased cellularity at the lesion site together with more abundant immunoreactive axons and Schwann cells. Compound muscle action potential (CMAP) amplitude was also higher in these animals, and CMAP latency was significantly lower. Treadmill performance increased in rats receiving GH. CONCLUSION GH enhanced the functional recovery of the damaged nerves, thus supporting the use of GH treatment, alone or combined with other therapeutic approaches, in promoting nerve repair.

DOI: 10.1002/mus.22303
020406020162017
Citations per Year

Citation Velocity: 12

Averaging 12 citations per year over the last 2 years.

Learn more about how we calculate this metric in our FAQ.

Cite this paper

@article{Devesa2012GrowthHT, title={Growth hormone treatment enhances the functional recovery of sciatic nerves after transection and repair.}, author={Pablo Devesa and Miguel Gelabert and Tamara Gonźlez-Mosquera and Rosal{\'i}a Gallego and Jos{\'e} Luis Relova and Jes{\'u}s Devesa and Victor Manuel Arce}, journal={Muscle & nerve}, year={2012}, volume={45 3}, pages={385-92} }