Growth hormone therapy in Noonan syndrome: growth response and characteristics.

@article{Westphal2009GrowthHT,
  title={Growth hormone therapy in Noonan syndrome: growth response and characteristics.},
  author={Otto Westphal},
  journal={Hormone research},
  year={2009},
  volume={72 Suppl 2},
  pages={41-5}
}
Growth hormone treatment in Noonan syndrome increases growth velocity significantly during the first 2 years of treatment and, to some extent, until puberty. This increase is more pronounced if treatment is started at an early age. Treatment before the age of 5 years is not recommended due to an increased risk of malignancies. In contrast to other growth hormone-treated patients, a slight but significant further increase in height gain can be expected during pubertal growth (at least in boys… CONTINUE READING

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