Growth hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin receptor substrates and Shc in rat tissues.

@article{Thirone1999GrowthHS,
  title={Growth hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin receptor substrates and Shc in rat tissues.},
  author={Ana Cl{\'a}udia Pelegrinelli Thirone and Carla Roberta de Oliveira Carvalho and M{\'a}rio Jos{\'e} Abdalla Saad},
  journal={Endocrinology},
  year={1999},
  volume={140 1},
  pages={55-62}
}
GH stimulates the tyrosine phosphorylation of various cellular polypeptides, including the GH receptor itself, in an early part of the intracellular response. Some of these phosphorylations are catalyzed by a GH receptor-associated kinase identified as JAK2, a member of the Janus family of tyrosine kinases. In cultured cells, GH stimulates the tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1), IRS-2, and Shc. This study investigated whether GH could cause the tyrosine… CONTINUE READING

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